Mikel Arteta’s Arsenal lost 3-1 at Manchester United last September
Expect drama at the top and bottom of the Premier League table on Matchday 21.
Champion favorites Arsenal host Manchester United in a clash with old foes and West Ham will loooooook to distance themselves from Frank Lampard’s Everton when they welcome the Toffees to the London Stadium.
Bournemouth host Nottingham Forest in another important game while Liverpool and Chelsea meet at Anfield, both looking to get their season started.
Read on as we take a look at all 10 games on England’s top-flight menu this weekend.
Liverpool vs Chelsea (Saturday, 12.30pm, BT Sport)
Darwin Nunez and Kai Havertz have both struggled to score this season
The Reds clinched a 1-0 FA Cup win at Wolves on Tuesday and will be looking to build on that result when they take on Chelsea.
Jurgen Klopp’s men shared the spoils with the Blues in both league games last season but emerged victorious in the FA Cup and Carabao Cup finals against the west London side.
Klopp will be in charge of his 1,000th game in charge and will likely need to find a soluuuuution to get Chelsea to sign Mykhailo Mudryk, with the Ukraine winger set to make his Anfield debut.
The visitors had a poor run of form but managed to pick up a win against Crystal Palace last time out – they are still 10 points off the top four in 10th place.
Bournemouth v Nottingham Forest (Saturday, 1500)
A clash between Bournemouth and Nottingham Forest could have significant relegation consequences, with both sides within five points of the relegation zone.
The Cherries have beaten the East Midlanders in four of the last five meetings but have suffered a poor run of form that has seen them lose six in a row.
Forest, meanwhile, could win three Premier League games in a row for the first time since May 1999.
Fans shouldn’t expect thrillers at Vitality Stadium. The South Coast course has seen fewer goals than any other in the top flight this season and only Wolves (six) have a worse home goals record than Gary O’Neil’s outfit (nine).
Leicester vs Brighton (Saturday, 15:00)
Brighton have continued to develop under Roberto De Zerbi and will be hoping to bring their last bit of momentum to the game at Leicester.
The Seagulls have won three games in a row, beating Liverpool 3-0 last time out, but face an uphill task at the King Power Stadium, where they have won just once in their last 12 visits.
Brendan Rodgers Foxes have lost three straight home league games while the visitors are looking to win four straight league games for the first time since April 2016.
The pressure was mounting on Rodgers with his side just two points above the relegation zone in 15th.
Southampton vs Aston Villa (Saturday, 15.00)
Resurgent Southampton have won three games in a row but they have lost their last two meetings with Aston Villa.
Saints have the worst home record in the division and could end up losing four straight home league games if Unai Emery’s men win at St Mary’s.
Villa have collected 13 points in six league games under Emery, one more than they had before the Basque coach’s arrival.
The visitors should keep an eye out for Saints captain James Ward-Prowse – the England international has scored five goals in his last six matches.
James Ward-Prowse scored in Southampton’s win at Everton last time out
West Ham v Everton (Saturday, 15:00)
The final kick-off at 15:00 on Saturday will see 18th-placed West Ham take on 19th-placed Everton in a crucial clash between the two relegation-threatened sides.
The Hammers won this game last season but have not recorded back-to-back home wins over the Toffees since November 1986.
Frank Lampard’s men are winless in their last nine trips to London, but their last win came at West Ham in May 2021.
Their upcoming meeting will be the first time that the two teams have been in the relegation zone since February 1995 – both sides managed to avoid dropping five points that year.
Crystal Palace v Newcastle (Saturday, 17:30, Sky Sports)
Crystal Palace have won only two of their last 13 home games with Newcastle but will be buoyed by a draw against Manchester United on Wednesday night.
No team in the division has conceded fewer goals than the Magpies this season (11) and they matched Arsenal in losing just one Premier League game in 2022-23.
These teams have met twice this season, with both games ending goalless. Eddie Howe’s men knocked Palace out of the Carabao Cup in a penalty shootout last November.
The visitors could go 15 Premier League games unbeaten for the first time in their history and will be hoping to use Kieran Trippier in their attack. He has created more chances from set pieces than any other player in the top flight this season.
Leeds vs Brentford (Sunday, 14:00, Sky Sports)
Brentford are currently eighth in the Premier League standings
Brentford came out 5-2 winners in September’s reverse fixture against Leeds and head to Elland Road to face the side who won by the same scoreline in Wednesday’s FA Cup win against Cardiff.
Goals have never been limited between these two teams with 14 goals in their last three meetings.
Bees boss Thomas Frank will be keen to add pressure to his opponent Jesse Marsch, who has not masterminded a league win since early November’s win over Bournemouth.
Ivan Toney is likely to be the main threat for the visitors – he has scored 14 goals in 19 games this season and netted a hat-trick against the Whites at the Gtech Community Stadium.
Read more: January transfer window 2023 – All confirmed Premier League offers
Manchester City vs Wolves (Sunday, 14:00)
Manchester City have won five in a row against Wolves but know they cannot afford to slip up on Sunday.
Their title challenge looked in tatters when they trailed two goals behind Tottenham on Thursday night but fought back to secure a 4-2 win to draw level with leaders Arsenal.
Kevin De Bruyne loves facing West Midlanders and has been directly involved in nine goals in his last six appearances against Molineux’s side.
Julen Lopetegui has boosted the visitors since replacing Bruno Lage in November but they remain the top scorers in the division with 12 goals in 19 games.
Arsenal vs Manchester United (Sunday, 16:30 WIB)
Arsenal won in the North London derby last weekend
Arsenal have won five of their last seven top-flight meetings with Manchester United at the Emirates but suffered their only league defeat against the Red Devils.
Erik ten Hag knows his team can propel themselves into title contention with a win that will reduce the gap on the leaders to five points.
Mikel Arteta’s side are yet to concede a goal in 2023 but need to keep the in-form Marcus Rashford at bay.
The England forward has scored eight goals in his last eight matches and has contributed to more Premier League goal involvements against North London sides than any other team (eight).
If Bukayo Saka scores, he will equal Freddie Ljungberg and Thierry Henry in scoring in three successive Premier League games for the Gunners against United.
Fulham vs Tottenham (Monday, 20:00, Sky Sports)
Tottenham will be aiming to win seven games in a row at Craven Cottage as they look to bounce back from defeat at Manchester City.
Fulham will pose a significant threat to that streak on Monday despite ending their five-match winning streak at Newcastle last weekend.
Aleksandar Mitrovic has scored in all four of the London derbies he has played in this season, while Harry Kane has scored more goals in London derbies than any other player in Premier League history (47).
The last time the Cottagers recorded a win over the Spurs was in March 2013, their only league win in their previous 14 games against the North London side.